סמינר מחלקה של דר' רם אדר - תיאוריית ג'ל פעיל להגירה רב תאית

School of Mechanical Engineering Seminar
Monday, November 7, 2022 at 15:00
Wolfson Building of Mechanical Engineering, Room 206

Active-gel Theory for Multicellular Migration

Dr. Ram Adar

   Institut Curie & College de France

Active materials are driven out of equilibrium by a constant consumption of energy at the microscopic level, which is converted into forces and motion. These include biological objects at different scales, ranging from active molecular motors to groups of animals. The physical theory that I will present is motivated by multicellular migration in tissues, which plays a key role in development, wound healing, and metastasis. We propose to describe it as permeation of an active, polar solvent in a viscoelastic environment. We formulate an active-gel theory that provides a simple description of the dynamic reciprocity between migrating cells and their environment in terms of distinct relative forces and alignment mechanisms. We make new predictions regarding multicellular migration modes based on these mechanisms. Namely, cellular alignment to elastic strains is expected to drive phase-separation in the cellular concentration and orientation for sufficiently extensile collections of cells. Our theory can serve as basis for the analysis of multicellular migration modes and cancer-cell invasion from tumors into connective tissues.

Short bio:

For the last three years, Dr. Adar has been a Rothschild Postdoc Fellow and a Fellow of the French Medical Research Foundation (FRM).

   Institut Curie & College de France, Paris, under Prof. Jean-François Joanny, examining Soft active matter & Biophysics. His current focus is on Cell-environment feedback at different scales. Before that he was a PhD Student at Tel Aviv University, School of Physics and Astronomy, under Prof. David Andelman dealing with Statistical mechanics of ionic fluids. There he studied the Effects beyond the Poisson-Boltzmann framework.

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https://tau-ac-il.zoom.us/j/4962025174?pwd=bVJUeElXRUUya3BERisyNllLOE9EZz09